Matrix Effects in Mass Spectrometry Combined with Separation Methods — Comparison HPLC, GC and Discussion on Methods to Control these Effects

Even in the early times of chromatography with conventional detectors (i.e. UV/VIS, FID) it became evident that different sample matrices present peculiar interfering compounds, and the importance of using appropriate spiked matrix calibrators in order to get reliable quanti‐ tative results was recognized. In these conditions, however, the main concern was the presence of coeluting compounds giving similar detector responses, while the risk to alter the detector response of the analyte was not yet an issue.